{"product_id":"9783659357312","title":"Anti-malaria Drugs and Plasmodium falciparum Gametocytes Prevalence : Gametocyte Prevalence and Drug Resistance following treatment of Uncomplicated Plasmodium falciparum Malaria (2013. 136 S. 220 mm)","description":"\u003cp\u003e§16§We monitored post-treatment Plasmodium falciparum among patients treated with chloroquine (CQ) and Fansidar (SP) in a village in eastern Sudan. Parasites were examined on day0, day7, day14 and day21 during the transmission season. A further sample was taken 2 months later (day80) at the start of the dry season. Asexual forms and gametocytes were detected by microscopy,and reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect expression of gametocyte-specific proteins pfs25 and pfg377. Microscopic gametocytes increased significantly following CQ and SP treatment, reaching a maximum between days7 and14. When measured by RT-PCR, however, there was no significant difference in gametocyte rate between day0 and days7 or 14. RT-PCR gametocyte rates dropped dramatically by day80 post treatment but were still 33% and 8% in the CQ- and SP-treated groups at this time. Drug resistance alleles to CQ (pfcrt,and pfmdr1) and to SP (dhfr) were seen at a high frequency at the §16§beginning of treatment and increased further through time following both drug treatments. Infections with drug-resistant parasites tended to have higher gametocyte prevalence than drug-sensitive infections\u003c\/p\u003e","brand":"LAP LAMBERT ACADEMIC PUBLISHING","offers":[{"title":"Default Title","offer_id":48775232749803,"sku":"00000_00000_00000_00000","price":116.68,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0758\/4484\/5803\/files\/9783659357312-1.jpg?v=1781727926","url":"https:\/\/kinokuniya.com.sg\/products\/9783659357312","provider":"Books Kinokuniya Singapore","version":"1.0","type":"link"}