{"product_id":"9783110469844","title":"Metallo-Drugs: Development and Action of Anticancer Agents : Development and Action of Anticancer Agents (Metal Ions in Life Sciences 18) (2018. XLII, 546 S. 150 col. ill., 100 b\/w tbl. 240 mm)","description":"\u003cp\u003eVolume 18, entitled \u003cem\u003eMetallo-Drugs: Development and Action of Anticancer Agents\u003c\/em\u003e of the series \u003cem\u003eMetal Ions in Life Sciences\u003c\/em\u003e centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of \u003cem\u003ecis\u003c\/em\u003e-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II\/III), Au(I\/III), Ti(IV), V(IV\/V), and Ga(III) including also the essential metal ions Fe(II\/III), Cu(I\/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, \u003cem\u003eMILS-18\u003c\/em\u003e summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the \u003cstrong\u003e17\u003c\/strong\u003e stimulating chapters of this book, written by \u003cstrong\u003e39\u003c\/strong\u003e internationally recognized experts from \u003cstrong\u003e10\u003c\/strong\u003e nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than \u003cstrong\u003e2700\u003c\/strong\u003e references, nearly \u003cstrong\u003e150\u003c\/strong\u003e illustrations (more than half in color) and several comprehensive tables. \u003cem\u003eMetallo-Drugs: Development and Action of Anticancer Agents\u003c\/em\u003e is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching. \u003c\/p\u003e \u003cp\u003eFrom the Content: \u003c\/p\u003e \u003col\u003e \u003cli\u003eIntroduction to the Wider Field of Metallo-Drugs \u003c\/li\u003e \u003cli\u003eCisplatin and Oxaliplatin: Our Current Understanding of Their Actions \u003c\/li\u003e \u003cli\u003ePolynuclear Platinum Drugs: Covalent and Non-covalent DNA-Binding Agents \u003c\/li\u003e \u003cli\u003eDifferent Drugs, Different Actions: The Actions and Consequences of Trans and Cationic Platinum Drugs \u003c\/li\u003e \u003cli\u003ePlatinum(IV) Drugs \u003c\/li\u003e \u003cli\u003eThe Ruthenium Drugs KP1019 and NAMI-A: Our Current Understanding of Their Actions \u003c\/li\u003e \u003cli\u003eRuthenium Piano-Stool Organometallic Drugs \u003c\/li\u003e \u003cli\u003eThe Gold Drugs \u003c\/li\u003e \u003cli\u003eTitanium Drugs \u003c\/li\u003e \u003cli\u003eVanadium Drugs \u003c\/li\u003e \u003cli\u003eNon-covalent Metallo-Drugs: Targeting Junction Structures \u003c\/li\u003e \u003cli\u003eMetallo-Drugs that Target Proteins \u003c\/li\u003e \u003cli\u003eNon-canonical Nucleic Acid Targets: Metallo-Drugs that Act on Quadruplexes \u003c\/li\u003e \u003cli\u003eTargeting, Delivery and Nanoscience of Metallo-Drugs \u003c\/li\u003e \u003cli\u003eMetallo-Intercalators \u003c\/li\u003e\n\u003c\/ol\u003e \u003cp\u003e\u003cstrong\u003eHelmut\u003c\/strong\u003e and \u003cstrong\u003eAstrid Sigel\u003c\/strong\u003e, University of Basel, Switzerland; \u003cstrong\u003eRoland K. O. Sigel \u003c\/strong\u003eand\u003cstrong\u003e Eva Freisinger\u003c\/strong\u003e, University of Zürich, Switzerland. \u003c\/p\u003e \u003cp\u003e\"The editors are to be congratulated for not only keeping the scientific community abreast of latest developments in this vibrant field of research but for providing an invaluable resource which will no doubt stimulate further cutting edge research in this domain. This volume will also act as an invaluable and indispensable reference source for postgraduate as well as undergraduate teaching. I cannot recommend it highly enough.\" \n\u003cem\u003eCeline J. Marmion in: Coordination Chemistry Reviews 371 (2018) 96-98\u003c\/em\u003e \u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e\"(...) \u003cem\u003eMetallo-Drugs: Development and Action of Anticancer\u003c\/em\u003e \u003cem\u003eAgents\u003c\/em\u003e is a nice collection of articles that serves a suitable introduction to either the novice or experienced researcher in the field.\" \n\u003cem\u003eSeth M. Cohen in: Journal of Inorganic Biochemistry 186 (2018) 103\u003c\/em\u003e \u003c\/p\u003e \u003cp\u003e\"Volume 18 of MILS is an excellent update on a vibrant field within Bioinorganic Chemistry, the role of metal species in the treatment of cancer. It reflects both the successes of metallo-drugs in the clinic, their failures and shortcomings, and at the same time also promises and hopes for improved drugs in the future. The book is, as stated by the editors, indeed an \"essential resource for scientists in this field\" and a valuable source for teachers of relevant Bioinorganic Chemistry courses.\" \n\u003cem\u003eBernhard Lippert in: Inorganica Chimica Acta 479 (2018) 247-248\u003c\/em\u003e \u003c\/p\u003e \u003cp\u003e\"(...) This volume currently represents the most up-to-date review within the field of metal-based anticancer agents. (...) A particular strength is the focus on the mechanistic studies and the biological targets, an important feature that makes it different from other reviews recently published. (...) The volume \u003cem\u003eMetallo-Drugs: Development and Action of Anticancer Agents\u003c\/em\u003e is strongly recommended not only to experienced scientists (either chemists, biologists, biochemists or pharmacologists), but also to researchers in the early stage of their career willing to gain preliminary knowledge on metallodrugs and their biological activity, so as acquire the theoretical background necessary to carry our successful research in the field.\" \n\u003cem\u003eLuca Ronconi in: Transition Metal Chemistry 43 (2018) 377-379\u003c\/em\u003e \u003c\/p\u003e \u003cp\u003e\"This latest volume of the series on \u003cem\u003eMetal Ions in Life Sciences\u003c\/em\u003e will be a valuable addition to libraries of researchers and institutions active in cancer research, but also a helpful source for advanced teaching of the subject.\" \n\u003cem\u003eHubert Schmidbaur in: Zeitschrift für Naturforschung B 73 (2018) 355-357\u003c\/em\u003e \u003c\/p\u003e","brand":"De Gruyter","offers":[{"title":"Default Title","offer_id":48808633237739,"sku":"00000_00000_00000_00000","price":677.54,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0758\/4484\/5803\/files\/9783110469844-1.jpg?v=1783114529","url":"https:\/\/kinokuniya.com.sg\/zh\/products\/9783110469844","provider":"Books Kinokuniya Singapore","version":"1.0","type":"link"}