The Irones and Their Precursors.- I. Introduction.- II. Isolation and Structure Determination.- III. Structure of the Irone Precursors.- IV. Stereochemistry of the Iridals and the Irones Derived from Them.- V. Minor Triterpenoids in Iris Extracts.- VI. Biogenesis of the Iridals.- VII. Mechanism of Irone Ring Formation.- VIII. Biological Significance of the Compounds.- References.- The Condylocarpine Group of Indole Alkaloids.- 1. Introduction.- 2. Structures.- 3. Isolation and Occurrence.- 4. Biogenesis.- 5. Chemistry.- 6. Physical Properties.- 7. Pharmacology.- References.- The Antibiotics of the Pluramycin Group (4H-Anthra[1,2-b]pyran Antibiotics).- 1. Introduction.- 2. General Structural Characteristics and Nomenclature.- 3. The Families of Pluramycin Antibiotics.- 4. Chemical Properties.- 5. Total Synthesis.- 6. Biosynthesis.- 7. Biological and Biochemical Behaviour.- Acknowledgement.- Note added in proof.- References.- Cyclosporine and Analogues - Isolation and Synthesis - Mechanism of Action and Structural Requirements for Pharmacological Activity.- 1. Introduction.- 2. Monoclonal Antibodies to Cyclosporine (1).- 3. The Biosynthesis of Cyclosporine.- 4. Synthesis of Cyclosporine.- 5. Biological Activity and Structure-activity Relationships of Cyclosporine Analogues.- 6. Mechanism of Action of Cyclosporin A.- References.- Biosynthesis of Iridoids and Secoiridoids.- I. Introduction.- II. Classification of Iridoids and Secoiridoids.- III. Mevalonoid Origin of Iridoids and Secoiridoids and Mechanism of Formation of Iridane Skeleton from Acyclic Monoterpenes.- IV. Biosynthetic Processes After Cyclopentane Ring Formation.- V. Biosynthetic Relationships Between Groups of Secoiridoid Glycosides.- VI. Biosynthetic Pathways of Alkaloidal Glycosides and Hydrangenosides.-VII. Epilogue.- List of Compounds.- References.- Author Index.
