Characterizing synthetic biology, as a more up-to-date term for genetic engineering, biochemists and bioengineers explore the field from the perspectives of design, synthesis, and manipulation of genomes; modifying the central dogma; experimental and computational approaches to the design and improvement of biological processes; applications to small molecule production; and applications to higher organisms. Among their topics are genome-editing technologies: principles and applications, at the interface of chemical and biological synthesis: an expanded genetic code, the need for integrated approaches in metabolic engineering, engineering gene circuits for mammalian cell-based applications, and phage therapy in the era of synthetic biology. Annotation 2018 Ringgold, Inc., Portland, OR (protoview.com)