§16§§This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients' symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life. § §04§§Acute kidney injury.- CRRT as treatment.- Water and solute movements: basic physiology.- CRRT modalities.- Hemodialysis (diffusive) versus hemofiltraion (Convective) CVVH.- CRRT Principles.- General consideration for CRRT.- Specific consideration for pediatric CRRT.- Vascular access and catheter size.- Blood flow rate (BFR) .- Ultrafiltation rates.- Calculating the desired fluid removal rate.- Replacement/dialysate solutions.- Drug dosing in CRRT.- Blood priming.- Nutrition in CRRT.- Monitoring during CRRT.- Compliance of CRRT.- Replacement/dialysate solution composition.- Factors influencing the clearance of drug during CRRT.- CRRT impact on pharmacokinetic parameters.- Case Studies.-§ §13§"The book is written for residents and practitioners in pediatric critical care and nephrology. ... It covers acute kidney injury, pharmacology of drugs in acute kidney injury, and continuous renal replacement therapy modalities." (Aftab Chishti, Doody's Book Reviews, September, 2017)§§"An updated practical guide for the treatment of acute kidney injury with didactic illustrations and tables. For pediatric nephrologists." (Zvi Laron, Pediatric Endocrinology Reviews, Vol. 13 (4), June, 2016)§ §02§§Farahnak Assadi, M.D.§ §Distinguished Professor, Emeritus § §Department of Pediatrics§ §Rush University Medical College§ § § § §Division of Nephrology§ §Rush Children's Hospital§ §Chicago, Illinois§ §USA§ § § § §Fatemeh Ghane Sharbaf, M.D. § §Associate Professor§ §Department of Pediatrics § §Section of Nephrology § §Mashhad University of Medical Sciences§
