§15§Dieses einzigartige Referenzwerk deckt die Biologie von Parasiten, heutige Arzneimittel, die neuesten Werkzeuge der Wirkstoffforschung, molekulare Targets sowie neuartige Therapeutika ab und ist ideal für alle Experten der Ektoparasitologie in der Veterinärmedizin und Medizin. §16§This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities.§Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strateg §16§ies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry. §04§PART ONE: Strategies 〓Comparison of Anti-Ectoparasite and Anti-Endoparasite Therapies and Control Strategies§Vaccination Against Ticks§Blocking Transmission in Vector-borne Diseases§The Threat and Reality of Drug Resistance in Cattle Tick Rhipicephalus (Boophilus) microplus§Monitoring Drug Sensitivity in Cattle Ticks§New Developments in the Control of Human Lice§ §PART TWO: Screens 〓Molecular Targets to Impair Blood Meal Processing in Ticks§Whole-organism Screens for Ectoparasites§In vitro Feeding Methods for Hematophagus Arthropods and Their Application in Drug Discovery§Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development§Testing in Target Hosts for Ectoparasiticide Discovery and Development§ §PART THREE: Isoxazolines§Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites§The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs§Development of Afoxolaner as a New §04§ Ectoparasiticide for Dogs§Discovery, Development, and Commercialization of Sarolaner (Simparica®), A Novel Oral Isoxazoline Ectoparasiticide for Dogs§Isoxazolines: Preeminent Ectoparasiticides of the Early Twenty-first Century§
