§04§Plenary Lecture: Drug-Induced Cardionecrosis.- Young Scientists Award Lecture 1983: Investigations into the Mechanism of Coumarin-Induced Hepatotoxicity in the Rat.- Alteration of Drug Toxicity in Disease States.- Toxic Effects on the Male Reproductive System.- Metabolism and Toxicity.- Toxicity of Non-steroidal Antirheumatic Drugs: Molecular Mechanisms and Clinical Assessment.- Heavy Metal Toxicity.- Xenobiotic Toxicology.- Miscellaneous Toxic Effects.- Novel and New Techniques in Toxicology.- Author Index. §04§eproductive System.- Effects of Drugs and Chemicals on Spermatogenesis.- Assessment of Chemicals Affecting the Male Reproductive System.- Toxic and Mutagenic Influences on Spermatogenesis.- Gonadal Damage in Hodgkin's Disease from Cancer Chemotherapeutic Regimens.- Approaches to the Suppression of Testicular Function for Male Fertility Control.- Morphological Changes Produced in Rat Testis by Anticancer Drugs.- Aspects of Testicular Toxicity Induced by Anticancer Drugs.- Changes in Germinal Tissue and Leydig Cells Correlated with Ethanol Consumption in Males with and without Liver Disease.- Testicular Effects of Some Xanthine Derivatives in the Rat.- Effects of Daily High Doses of Paracetamol Given Orally During Spermatogenesis in Rat Testes.- The Effects on the Rat Testis of Single Inhalation Exposures to Ethylene Glycol Monoalkyl Ethers, in Particular Ethylene Glycol Monomethyl Ether.- Effects of an Indenopyridine Derivative, Compound 20-438, on Spermatogonial Stem Cells of the §04§Rat.- Monitoring Chemically Induced DNA Damage in the Germ Cells of Male Mice.- Accumulation of Toxic Metals in Male Reproduction Organs.- Metabolism and Toxicity.- Active Metabolites in Toxicology: The Role of Cytochrome P-448 and Flavoprotein Oxidases.- The Role of Pharmacokinetics in the Design and Interpretation of Toxicological Studies.- Structural Characteristics of Compounds That can be Activated to Chemically Reactive Metabolites: Use for a Prediction of a Carcinogenic Potential.- Covalent Binding to Proteins as a Mechanism of Chemical Toxicity.- Species Differences in Oxidative Drug Metabolism: Some Basic Considerations.- Human Pharmacokinetics and Safety of Boric Acid.- The Influence of Paracetamol on the Hepatic Biosynthesis of Lecithin.- Decreased Blood Levels of Ethanol and Acetaldehyde by S-Adenosyl-L-Methionine in Humans.- Metabolic Activation of 2-Aminofluorene in the Salmonella Mutagenicity Assay by Different S-9 Preparations.- Reduction of Covalent Binding of Afl §04§atoxin B1 to Rabbit Liver DNA After Immunization Against this Carcinogen.- Inactivation of 2-Amino-3-methyl-imidazo (4,5-f) quinoline by Horse Radish and Intestinal Peroxidase.- The Influence of Two Histamine H2-Receptor Antagonists, Cimetidine and Ranitidine, on the Plasma Levels and Clinical Effect of Nifedipine and Metoprolol.- Autoradiography of 2,4?,5-Trichlorobiphenyl Mercapturic Acid Indicates the Formation of Methyl Sulphone Metabolites with Selective Affinity for the Bronchial Mucosa.- Methadone Affects the Histochemical Pattern of Xenobiotic-Metabolizing Enzymes in the Liver of Pregnant Rats.- The Effects of Acetylcysteine on Liver Glutathione Depletion and Hepatic Necrosis Induced by Acetaminophen in Mice.- Increased Microsomal Metabolism of n-Hexane in Rat Kidney and Liver After Inhalation of Isopropanol.- Dose-Dependent Pharmacokinetics of Clofibric Acid in the Non-human Primate.- Different Pathways of Chloroform Metabolism.- In Vitro Inhibition of Lysosomal Phospholi §04§pases by Aminoglycoside Antibiotics: A Comparative Study.- Erythrocyte-Dependent Metabolic Activation of Styrene and Induction of Sister Chromatid Exchange in Cultured Human Lymphocytes.- Interaction of Acrylonitrile with the Liver Mixed Function Oxidases.- Induction of Microsomal Enzymes after Inhalation of Methanol.- Erythromycin Estolate Impairs the Mitochondrial and Microsomal Calcium Homeostasis: Correlation with Hepatotoxicity.- Relationships Between the Pharmacokinetics of Carbon Tetrachloride Conversion to Carbon Dioxide and Chloroform and Liver Injury.- Distribution and Metabolism of 2-t-Butyl-4-methoxyphenol in the Everted Rat Gut Preparation.- Phenytoin Metabolites in Human Placental Tissue.- The Placental Transfer and Detection of 14C-Carmoisine Metabolites by HPLC Combined with a Radioactivity Monitor (RAM).- Toxicity of Non-steroidal Antirheumatic Drugs: Molecular Mechanisms and Clinical Assessment.- A Biochemical Basis for the Gastrointestinal Toxicity of Non-steroi
