Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling (NATO Asi Series (Closed) / NATO Asi Subseries H: (Closed)) <76>

§06§ §16§Nearly every cellular activity, such as cell growth,§proliferation, protein synthesis, and nuclear division, is§regulated by protein phosphorylation/dephosphorylation on§tyrosine residues as initiation events.Synchronization§occurs through interaction of protein tyrosine kinases and§phosphatases.§This book unveils signal pathways that connect§extracellular signals with changes of phosphorylation state§of target proteins allowing coordinated and integrated§modulation of mitogenic signalling. Specifically, cascades§involving protein serine/threonine kinases and connections§to phosphoinositides derived second messengers are§discussed.