This volume outlines a comprehensive series of chapters focused on various aspects of endogenous hypercortisolism contributed by an international team of specialists in endocrinology. The following chapters are included in the volume: 1. Clinical presentation and comorbidities: Examines how Cushing's syndrome manifests and related health conditions; 2. Biochemical diagnosis of hypercortisolism: Details diagnostic approaches for hypercortisolism, including timing and methodology; 3. ACTH-independent Cushing syndrome: Focuses on diagnosis and causes of ACTH-independent forms; 4. Bilateral macronodular and micronodular hyperplasia: Covers biochemical, radiological, and genetic diagnosis; 5. Differential diagnosis between endogenous and pseudo-Cushing: Provides strategies to distinguish between true Cushing's and pseudoCushing; 6. Differential diagnosis of ACTH-dependent Cushing's syndrome: Discusses hormonal and imaging studies for distinguishing ACTH-dependent cases; 7. Ectopic Cushing's syndrome: Reviews clinical features and diagnosis of ectopic ACTH production; 8. Cyclic Cushing's syndrome: Presents the clinical course and diagnosis of cyclic forms; 9. Mild autonomous cortisol secretion: Explores diagnostic criteria for mild autonomous cortisol excess; 10.Cushing's syndrome in pregnancy: Describes presentation and diagnosis during pregnancy; 11.Molecular profile of Cushing's syndrome: Details genetic and molecular characteristics; 12. Cardiometabolic comorbidities in overt Cushing's syndrome: Discusses cardiovascular and metabolic risks associated with the syndrome; 13.New tools for diagnosis: Introduces innovative diagnostic methods for hypercortisolism. Each chapter is written by experts from leading medical institutions across Europe and Latin America. The chapters collectively offer a broad, in-depth exploration of Cushing's syndrome—from clinical presentation and differential diagnosis to molecular profiling and advances in diagnostic technology.
