This concise text provides acomplete overview of alternating electric fields therapy -- also known as tumortreating fields -- for glioblastoma and other types of solid tumormalignancies. Readers are given a fundamental understanding of this novelanti-cancer treatment modality by learning from clinical trial data as well asthe physical and cell biology effects on tumor cells when alternating electricfields are applied both in vitro and in vivo.
Chapters illustrate the physicsbehind electric field propagation in space and other media. This isfollowed by a review of our current understanding of the electric field effectson dividing cells - including the disruption of cytokinesis, proper chromosomesegregation and activation on the cell surface chaperons that induceimmunogenic cell death. Data from phase III trials for the treatment ofrecurrent and newly diagnosed glioblastomas are included, as well as some ofthe ancillary post hoc analyses thatwere performed by variousinvestigators. The remainder of the chapter covers other solid tumormalignancies, including non-small cell lung cancer, pancreatic cancer andovarian cancer, as this treatment modality is being applied to systemicmalignancies.
Alternating Electric FieldsTherapy in Oncology offers oncologists,neurologists, radiation oncologists, biomedical engineers, cell biologists andmitosis researchers the fundamentals needed for clinical practice.
1. Cell Biological Effects of Alternating Electric Fields.- 2. Fundamental Physics of Alternating Electric Fields Therapy.- 3. Biophysical Effects of Alternating Electric Fields.- 4. Computer Simulation of Alternating Electric Fields Therapy.- 5. Response Pattern and Modeling of Tumor-Treating Fields.- 6. Clinical Efficacy of Alternating Electric Fields for Recurrent Glioblastoma.- 7. Alternating Electric Fields in Clinical Practice with Emphasis on PRiDe Registry.- 8. Alternating Electric Fields Therapy for Newly Diagnosed Glioblastoma.- 9. Supportive Care in Patients Using Alternating Electric Fields Therapy.- 10. Future Directions for Alternating Electric Fields.
Eric T. Wong, MD
Associate Professor of Neurology
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA 02215, USA
