Molecular and biochemical studies of Alzheimer's disease have recently undergone a major revolution with the discovery of the presenilin genes. An understanding of the mechanisms by which mutations in the presenilin genes cause neurodegeneration and dementia should greatly facilitate the development of novel strategies for treating Alzheimer's disease and related disorders. Molecular Genetics of the Presenilins in Alzheimer's Disease.- Alzheimer's Disease: A Matter of Dominance.- Alternative Endoproteolysis of the Presenilins and Familial Alzheimer's Disease.- The APP and PS1/2 Mutations Linked to Early Onset Familial Alzheimer's Disease Increase the Extracellular Concentration of A?1-42(43).- Metabolism and Function of Presenilin 1.- Mechanistic Studies of the Effect of Presenilins 1 and 2 on APP Metabolism.- Presenilin 2 - APP Interactions.- The Cellular Biology of Presenilin Proteins and a Novel Mechanism of Amyloid ?-Peptide Generation.- Regulation of Presenilin 1 Phosphorylation and Transcriptional Activation of Signal Transduction-Induced Genes by Muscarinic Receptors.- Neuronal Regulation of Presenilin-1 Processing.- Transgenic Approaches to the Study of Alzheimer's Disease. Molecular and biochemical studies of Alzheimer's disease have recently undergone a major revolution with the discovery of the presenilin genes. An understanding of the mechanisms by which mutations in the presenilin genes cause neurodegeneration and dementia should greatly facilitate the development of novel strategies for treating Alzheimer's disease and related disorders.
