This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume is intended not only for those active in research into metalloproteinases but also for those with an interest in inflammatory diseases. Thus it addresses both academic and industrial researchers. Structural characteristics of the matrix metalloproteinases.- Matrix metalloproteinase inhibitors.- Role of stromelysin-1 in cartilage metabolism.- Matrix metalloproteinases in neuro-inflammatory disease.- Membrane type matrix metalloproteinases: Regulators of focal proteolysis.- Aggrecanase and cartilage proteoglycan degradation.- Overview of the biological roles of metalloproteinases in health and disease.- Adhesion molecule sheddases.- TNF? converting enzyme.
