§16§In November 1998 many of the key leaders of new drug discovery for §inflammatory diseases gathered at Hershey, Pennsylvania for the 9th §International Conference of the Inflammation Research Association. The §Conference was held over a five day period and provided a stimulating §environment for the open exchange of important advances in basic §inflammation research as well as new drug discovery and development. §This book encompasses some of the highlights of several presentations §made at the Conference. It contains some of the latest and important §developments in the field of inflammation research. §Topics include the status of eotaxin and chemokines in asthma and §allergy, signal transduction and regulation of diverse mediators such as §the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as §regulators of AP-1, macrophage metalloproteinases, lymphotoxin and §further insights into the role of MCP-1 in disease. Also discussed are §drug targets in rheumatoid and §16§ osteoarthritis, fibrotic diseases,... §04§Contents. List of Contributors. Preface. T.J. Mitchell and T.J. §Williams: The role of eotaxin and related CC-chemokines in asthma and §allergy. Roger J. Davis: Signal transduction by the JNK group of MAP §kinases. Marie Chabot-Fletcher: TNF and IL-1 signaling to NF-kB. Anthony §M. Manning: Small molecule regulators of AP-1 and NF-kB. Robert T. §Abraham: Mammalian target of rapamycin: Immunosuppressive drugs offer §new insights into cell growth regulation. Catherine A. Burton, John §Boylan, Candy Robinson, Janet Kerr and Pamela Benfield: Constitutive §expression of a tumor suppressor leads to tumor regression in a §xenograft model. Steven D. Shapiro: Macrophage metalloproteinases in §destructive inflammatory diseases. Nancy H. Ruddle: Lymphotoxin in §inflammation and lymphoid organ development: Variations on a theme. §Steven L. Kunkel, Sem H. Phan, Nicholas W. Lukacs, Cory Hogaboam and §Stephen W. Chensue: Chemokine/cytokine biology during the evolution of §fibrotic disease. Long §04§Gu, Susan C. Tseng and Barrett J. Rollins: The §role of MCP-1 in disease. Lisa A. Beck, Cristiana Stellato, Syed §Shahabuddin, Renate Nickel and Robert P. Schleimer: The role of §chemokines in allergic diseases of the airways. James Winkler and Ken §Tramposch (coordicators): Ninth International Conference of the §Inflammation Research Association, November 1-5, 1998: Summaries of §workshops and poster discussions. William Williams and Elizabeth Arner §(chair persons): Targets in rheumatoid and osteoarthritis. Lawrence §Wennogle and Nancy Cusack (chair persons): Signal transduction and §regulation of gene expression. James Burke and Floyd Chilton (chair §persons): Mediators in inflammation and their enzymes. Denis Schrier and §Fandrew Issekutz (chair persons): Cell adhesion molecules and leukocyte §trafficking. Robert M. Strieter and David Underwood (chair persons): §Pulmonary inflammation, fibrosis, and disease. W. Hunter and E. Turley §(chair persons): Angiogenesis, wound repair §04§and skin inflammation. §Index.
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