The 18 chapters presented by editors Samuels (biological sciences, U. of Montana) and Radolf (genetics and developmental biology, U. of Connecticut Health Center) in this text provide encyclopedic coverage of the microbiological, immunological, genetic, and epizootic facets of pathogenic Borrelia, the Lyme disease spirochete. Specifically, they discuss the global history of Lyme borreliosis; Borrelia genomics; replication of the Borrelia genome and scrambling of the linear replicons through reverse telomere resolution; gene regulation, transciptomics, and proteomics; metabolism and physiology of Borrelia; structure, function, and biogenesis of the Borrelia cell envelope; the chic motility and chemotaxis of Borrelia; genetic manipulation of Borrelia; the evolutionary genetics of Borrelia; the ecology of Borreliae and their arthropod vectors; tick interactions; pathobiology of Lyme disease Borrelia; pathogenesis of relapsing fever; animal models of Borreliosis; host response; detection of Borrelia; Lyme disease vaccines; and Lyme disease in humans. Distributed in the US by ISBS. Annotation 2010 Book News, Inc., Portland, OR (booknews.com)
