In this volume aimed at neurobiologists, cell biologists, pathologists, other scientists, investigators, clinicians, and students, Selkoe (Harvard Medical School) et al. compile 25 chapters by researchers in neurology, neuroscience, molecular biology, genetics, and other specialties in the US, Europe, Japan, and Australia who summarize research on the biology of Alzheimer disease. They discuss the biochemistry and cell biology of amyloid beta-protein precursor, tau, presenilin, beta-secretase, and apolipoprotein E and their involvement in the disease, as well as its clinical, neuropathological, imaging, and biomarker phenotypes; associated genetic alterations; and epidemiological insights into its cause and pathogenesis. Coverage also includes diagnostic issues, the neuropsychological profile of the disease, frontotemporal dementia, animal models, inflammation, treatment strategies, and the future of the disease. Annotation 2012 Book News, Inc., Portland, OR (booknews.com)
