§16§This unique book presents an up-to-date discussion of clinical disorders of the pituitary gland in children with specific emphasis on state-of-the-art diagnostic and treatment modalities, highlighting the newest scientific advances in genomics and molecular biology that clinician-scientists caring for children need to know. Chapters focus on the current knowledge base in genomics, pathophysiology, diagnosis, and medical and surgical management, organized into thematic sections. Part I discusses embryologic and genetic disorders, including genomics and congenital disorders of the pituitary. Part II presents acquired pituitary disorders, such as prolactinomas, Cushing's Disease, and both hormone secreting and non-secreting pituitary tumors. Subsequent sections cover posterior pituitary disorders, such as diabetes insipidus, functional hormone deficiencies of the hypothalamic-pituitary axis, including delayed puberty and pubertal disorders and growth hormone disorders, neuro-opthalmi §16§c disease, CNS radiation, childhood cancer treatment and traumatic brain injury. §§Authoritative and comprehensive, Pituitary Disorders of Childhood will serve as a precise guide for clinical endocrinologists and will guide future investigation into translational and clinical research on the pediatric pituitary. §04§Part I. Embryologic and Genetic Disorders of the Pituitary Gland.- Genomics.- Genetics of Hypopituitarism.- Part II. Acquired Pituitary Disorders: Pituitary Tumors and Nonpituitary Sellar Masses.- Adamantinomatous Craniopharyngioma: Genomics, Radiologic Findings, Clinical, Prognosis.- Prolactinomas.- Cushing's Disease: Diagnosis and Treatment.- Surgery for Cushing's Disease.- Gigantism and Acromegaly.- TSH Secreting Pituitary Adenomas.- Molecular Predictors of Clinical Behavior in Pituitary Adenohypophysial Tumors.- Nonpituitary Sellar Masses and Infiltrative Disorders.- Part III. Posterior Pituitary Disorders.- Posterior Pituitary Disorders: Anatomy and Physiology; Central Diabetes Insipidus (CDI); Syndrome of Inappropriate Anti-diuretic Hormone (SIADH).- Part IV. Functional Hypothalamic-Pituitary Hormone Deficiencies.- Congenital Hypogonadotropic Hypogonadism (Isolated GnRH Deficiency).- Genetics of Delayed Puberty.- Hypothalamic Amenorrhea.- Part V. Neuro-opthalmic Diseases.- N §04§euro-ophthalmic Diseases and Endocrinologic Function.- Part VI. CNS Radiation.- CNS Radiation of Childhood CNS Tumors.- Part VII. Childhood Cancer Treatment.- Hypothalamic-Pituitary Dysfunction as a Late-Effect of Childhood Cancer, Brain Tumors and their Treatments.- Part VIII. Traumatic Brain Injury.- Pituitary Response to Traumatic Brain Injury. §02§Brenda Kohn, MD, Associate Professor, Department of Pediatrics, Director, Division of Pediatric Endocrinology and Diabetes, NYU Langone Medical Center, New York, NY, USA
